CALL FOR PAPERS Novel Therapeutics in Renal Diseases Magnesium protects against cisplatin-induced acute kidney injury by regulating platinum accumulation
نویسندگان
چکیده
Malvika H. Solanki, Prodyot K. Chatterjee, Madhu Gupta, Xiangying Xue, Andrei Plagov, Margot H. Metz, Rachel Mintz, Pravin C. Singhal, and Christine N. Metz Elmezzi Graduate School of Molecular Medicine, Manhasset, New York; The Center for Immunology and Inflammation, Feinstein Institute for Medical Research, North Shore-LIJ Health System, Manhasset, New York; and Hofstra North ShoreLIJ School of Medicine, Manhasset, New York
منابع مشابه
Magnesium protects against cisplatin-induced acute kidney injury by regulating platinum accumulation.
Despite its success as a potent antineoplastic agent, ∼25% of patients receiving cisplatin experience acute kidney injury (AKI) and must discontinue therapy. Impaired magnesium homeostasis has been linked to cisplatin-mediated AKI, and because magnesium deficiency is widespread, we examined the effect of magnesium deficiency and replacement on cisplatin-induced AKI in physiologically relevant o...
متن کاملMagnesium protects against cisplatin-induced acute kidney injury without compromising cisplatin-mediated killing of an ovarian tumor xenograft in mice.
Cisplatin, a commonly used chemotherapeutic for ovarian and other cancers, leads to hypomagnesemia in most patients and causes acute kidney injury (AKI) in 25-30% of patients. Previously, we showed that magnesium deficiency worsens cisplatin-induced AKI and magnesium replacement during cisplatin treatment protects against cisplatin-mediated AKI in non-tumor-bearing mice (Solanki MH, Chatterjee ...
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Objective(s): Cisplatin is an effective antineoplastic agent; its clinical utility, however, is limited by a few salient toxic side effects like nephrotoxicity. This study aimed to determine the potential protective effects of tangeretin, a citrus-derived flavonoid, against renal tubular cell injury in cisplatin-induced renal toxicity of rats.Materials and Methods: Tangeretin was injected intra...
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A major area in cancer therapy is the search for protective strategies against cisplatin-induced nephrotoxicity. We investigated the protective effect of cilastatin on cisplatin-induced injury to renal proximal tubular cells. Cilastatin is a specific inhibitor of renal dehydrodipeptidase I (DHP-I), which prevents hydrolysis of imipenem and its accumulation in the proximal tubule. Primary cultur...
متن کاملEffect of Glutathione on Cisplatin-Induced Nephrotoxicity in Male and Female Rats
SUMMARY Cisplatin is a widely used anticancer agents that is effective against ovarian and other tumors. This drug is recognized as nephrotoxic in human and experimental animals. The effect of cisplatin-induced kidney injury was predominantly investigated in male animals. This study was designed to assess effects of cisplatin on male and female rat kidneys. We also investigated the effect of g...
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تاریخ انتشار 2014